2015

1/31/15 - m-spike 1.4

2/17/15 - m-spike 1.5 to start study

• began SAR650984 study. 
• Includes 40mg dex and 25mg revlimid. 
• Had a pretty serious reaction during infusion. 
• Throat tightened (hard to swallow)
• head stopped up, and chest tightness
• Stopped treatment for an hour but then restarted and everything was fine. 
• Zometa treatment 

2/24/15 - treatment, noticed immediately less pain in feet and knees, result of taking dex again. 

3/03/15 - treatment 

3/10/15 - treatment 

3/17/15 - m-spike 1.0 after 1 month of treatment 

4/17/15 - m-spike 0.7 after 2 months of treatment 

5/17/15 - m-spike 0.6 after 3 months of treatment 

5/14/15 - 5/18/15 admitted to hospital with pneumonia and para influenza

6/17/15 - m-spike 0.6 after 4 months of treatment

• Zometa treatment 

7/17/15 - m-spike 0.6 again

8/17/15 - m-spike 0.4 !!   

9/01/15 - m-spike 0.5  

• Zometa treatment

10/01/15 - m-spike 0.3

11/01/15 - m-spike 0.3

11/24/15 - m-spike 0.3 

• Zometa treatment
• SAR650984 is given a name: Isatuximab.
• daratumumab (Darzalex) approved by FDA (close to Isatuximab)
• Ixazomib (Ninlaro) (next gen of velcade, carfilzamib, but in pill form) approved by FDA
• Elotuzumab (Empliciti) approved by FDA

12/22/15 - m-spike 0.2